Spearheading
the Global Expansion of China's Top
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把中国顶尖药品推向世界
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Spearheading
the Global Expansion of China's Top
Pharma & TCM Firms
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Global Spearhead of
China's Top Pharmaceutical & TCM Firms
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LIVOTIDE 古蔺肝苏 - Turn the Tide of Liver Decline
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Product Summary Used in the treatment of acute and chronic hepatitis and alcohol detoxification. Protects liver cells and improves the efficacy of the liver. · Strengthens & Protects the Liver · Detoxification · Alleviates Jaundice
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Livotide (Gulin Gansu) is used by more than 2,000 hospitals in China for the treatment of acute and chronic hepatitis, alcohol detoxification and fatty liver. It has the honour of being China’s first geographically protected TCM, made from the mountain herb penthorum Chinese Parsh. Livotide protects and improves the liver’s efficacy, reduces jaundice and lowers ALT and AST levels, amongst other functions. Livotide’s claims are backed by scientific studies published in various journals. Livotide can be used for the long term with no known side effects. Livotide Fast Facts
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· Treats acute & chronic hepatitis · Protects the liver & lowers transaminase （ALT/AST）levels · Promotes gall bladder function & reduces jaundice · Treats liver fibrosis · For Hepatitis B carriers, it protects the liver cells & prevents liver fibrosis · Promotes blood circulation, reduces blood stasis · Promotes diuresis which reduces edema, regulates qi. · Clears away heat and detoxifies · Regulates the immune function · Suppresses precancerous lesions · Gets rid of dampness · Strengthens the spleen · Has almost no side effects, can be used for the long term |
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Livotide – 3 Key Functions 1) Strengthens & Protects the Liver · Reduces serum levels of ALT/AST enzymes1,3,4. ALT/ AST normalization rates reached 76.67% and 73.08% respectively4, an indication of the recovery of liver cells from damage. · Improves liver ultrasound scan1, by achieving a less-enlarged shape, clearer outline, more uniform solid echo, less weakened far field echo, clearer liver surface echo frequency etc. · Reduces inflammation and pain in the liver area1,3,4. · Assists in relieving the symptoms of fatty liver, viral & alcoholic hepatitis, fibrosis and other liver problems1,3,4,5. 2) Alleviates Jaundice · Reduces and normalizes bilirubin levels (TBil) in the blood serum3,5, in cases of jaundice brought about by hepatitis and other liver disorders. · No rebound of jaundice symptoms even after withdrawal. 3) Detoxification of Alcoholic & Dietary Toxins Alcohol Detoxification · Removies alcohol from the blood serum by inducing the liver to breakdown alcohol2. · Delays intoxication onset2 by 4 times. Livotide: 249 minutes vs Control: 62 minutes. · Lessens intoxication extent2 by 30%. · Shortens intoxication timespan2. Livotide: 293 minutes vs Control: 340 minutes. Dietary Toxins Detoxification · Livotide strengthens, protects and detoxifies the liver, turning the tide of liver decline brought about by the inadvertent consumption of dietary toxins like pesticides, animal hormones, preservatives, natural toxins and certain prescription drugs. Livotide’s Chemical Composition · Contains high concentrations of Quercetin9 and Gallic Acid9. · Also contains Quercetin-3-O-α-L-rhamnoside, β-sitosterol, 2, 6-dihydroxyacetophenon-4-O-β-D-glucoside and Pinocembrin-7-O-β-D-glucoside. Mode of Action: Quercetin & The Liver Anti-inflammatory Quercetin inhibits several initial inflammatory pathways to help alleviate hepatitis (liver inflammation) and liver damage. · Pathway 1 - Quercetin downregulates the activity of intercellular adhesion molecule 1 (ICAM-1) in human endothelial cells by inhibiting the activator protein-1 (AP-1) and JNK pathway. Am J Physiol. 1999 Sep;277(3 Pt 1):C403-11. · Pathway 2 - Quercetin inhibits the gene expression of tumor necrosis factor alpha (TNF-α), a pro-inflammatory cytokine, as well as Monocyte chemotactic protein-1 (MCP-1) in normal peripheral blood mononuclear cells via modulation of the nuclear factor-kappa B (NF-kappa B) system7. Clin Vaccine Immunol. 2006 Mar;13(3):319-28. · Pathway 3 - Quercetin regulates Cox-2 mRNA transcription, and inhibits processes like PGE-2 synthesis, the production of RANTES and macrophage-inflammatory protein-2 (MIP-2). Life Sci. 2003 Dec 26;74(6):709-21. Antioxidant Quercetin guards the stability and structure of liver cells against ethanol-induced oxidative stress in mice liver, by inhibiting MDA production and enhancing the release of endogenous antioxidant enzymes CAT, SOD and GSH-R. Biol. Pharm. Bull. 26(10) 1398—1402 (2003) Vol. 26, No. 10 Anti-fibrosis Quercetin is dose dependent in reducing serum-driven HSC-T6 cell proliferation and collagen synthesis associated with a suppression of type I procollagen mRNA level in rat hepatic stellate cells. This might have a protective role in liver fibrosis. Acta Pharmacol Sin. 2001 Sep;22(9):793-6. For rats with carbon tetrachloride-induced cirrhosis, a 3-week treatment of Quercetin improved liver histology and reduced collagen content, iNOS expression and lipid peroxidation6. This might have a protective role in liver fibrosis. Dig Dis Sci. 2003 Apr; 48(4): 824-9. Anti-tumour Quercetin is capable of inducing selective growth inhibition and apoptosis in hepatic tumour cells, but not in normal cells. It can stimulate the antioxidant defense systems including SOD, CAT, GSH, and GR in normal hepatic cell line, but reduce SOD and increase MDA content in SV40-transformed cell line (tumour cells). Eur J Pharmacol. 2004 Oct 19;502(3):195-204 Mode of Action: Gallic Acid & The Liver Anti-inflammatory Gallic acid inhibits mast cell-derived inflammatory allergic reactions by blocking histamine release and pro-inflammatory cytokine expression, which helps in alleviating hepatitis8. Toxicol Sci. 2006 May;91(1):123-31. Anti-oxidant Gallic acid activates MGST1 (microsomal glutathione S-transferase) through oxidative modification of the enzyme. Life Sci. 2005 Nov 19;78(1):99-106. Anti-tumour Gallic acid inhibits the proliferation of metastatic tumour cells in the liver such as P815 murine mastocytoma, B16 murine melanoma and L5178 murine lymphoma cells. Anticancer Research 27: 3875-3880, 2001. Directions for Use Each 500 mg capsule contains 334 mg of Herba Penthori Chinensis extract, equivalent to 5.57 g of raw herbs. a) Fatty Liver Treatment Dosage: Take 3 capsules 2 times a day for 3 months. Repeat if necessary. Maintenance Dosage: Take 3 capsules once a day. b) Detoxification (Alcohol & Dietary) / Hepatitis Virus Carriers / Liver Supplement Treatment Dosage: Take 3 capsules once a day for 3 months. Repeat at intervals of 2 months or sooner. For alcohol detoxification, take 3 capsules half an hour before alcohol consumption. c) Acute and chronic hepatitis, liver fibrosis, liver cirrhosis and liver cancer. Treatment Dosage: Take 3 capsules 3 times a day for 3 months. Repeat if necessary. Maintenance Dosage: Take 3 capsules once a day. References 1. Clinical Observations on the Treatment of Fatty Liver with the Combined Use of Gansu Granules (Livotide) & ZhiBiTuo (red yeast rice) Capsules. Chen ZJ and Yuan CY. Guangdong CongHua Chinese Medicine Hospital. Hubei Chinese Medicine Magazine, 25:3. 2003. 11-12. 2. Effects of Herba Penthori Chinensis (Livotide) in Preventing and Delaying Alcohol Intoxication and Performing Alcohol Detoxification. Sichuan University Hua Xi School of Public Health. Report no. WJ200504005. May 2005. 3. Treatment of Viral Hepatitis with Livotide on 386 cases Sun QS, Ding WM, Li YF. Jiangsu Province, Huai An City, No. 4 Renmin Hospital. 355-6. Chinese Journal of Integrated Traditional & Western Medicine on Liver Diseases, 6:11. 2001. 355-356. 4. Observations on the Clinical Curative Effects of Gansu Granules (Livotide) on Chronic Hepatitis B. Chen XY, Yao H, Jiang Y, Wu SM, Zhu XF, Zhou XQ, Cai YM, Zhuo YH, Chen JJ, Wang LT. Chin J Hepatol, 12:1. Jan 2004. 50. 5. Clinical Observations On The Use Of Gansu Granules (Livotide) In The Treatment Of Liver Disease Associated With Jaundice Hong DL. Department of Infectious Diseases, First Affiliated Hospital of Nanjing Medical University (Jiangsu, Nanjing, 210000). Journal of Chinese Physician, 4:5. May 2002. 550. 6. Effects of Quercetin on Liver Damage in Rats with Carbon Tetrachloride-Induced Cirrhosis A Pavanato, Tunon MJ, Sanchez-Campos S, Marroni CA, Llesuy S, Gonzalez-Gallego J, Marroni N. Digestive Diseases and Sciences, 48:4. Apr 2003. 824-829. 7. The Flavonoid Quercetin Inhibits Proinflammatory Cytokine (Tumor Necrosis Factor Alpha) Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-κB System. Nair MP, Mahajan S, Reynolds JL, Aalinkeel R, Nair H, Schwartz SA, Kandaswami C. Department of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, State University of New York at Buffalo, 14203. Clinical and Vaccine Immunology, 13:3. Mar 2006. 319-328. 8. Gallic Acid Inhibits Histamine Release and Pro-inflammatory Cytokine Production in Mast Cells. Kim SH, Jun CD, Suk K, Choi BJ, Lim H, Park S, Lee SH, Shin HY, Kim DK, Shin TY. Kyungpook National University (Daegu), Kosin University Gospel Hospital (Pusan), Yeungnam University (Kyongsan), Woosuk University (Jeonbuk), Republic of Korea. Toxicological Sciences, 91:1. 2006. 123-131. 9. Isolation and identification of a novel flavonoid from Penthorum chinense P. Wang HW, Liu YQ, Feng CG. Department of Light Industry and Chemistry, Zhaoqing Univeristy. J Asian Nat Prod Res, 8:8. Dec 2006. 757-61.
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