Spearheading
the Global Expansion of China's Top
Pharma & TCM Firms
把中国顶尖药品推向世界
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Spearheading
the Global Expansion of China's Top
Pharma & TCM Firms
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Global Spearhead of
China's Top Pharmaceutical & TCM Firms
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KARDIGEN 活血珍
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Product Summary
KardiGen’s 3 AIMs for the Heart: Antioxidant Shield for the Heart Ischemic Angiogenesis Microcirculation Fast Facts · Comprises 5 cardioprotective antioxidants, isolated and concentrated from Herba Leonuri, a herb with a 2,000-year history in Traditional Chinese Medicine. · Jointly researched by the National University of Singapore and China’s prestigious Fudan University for 7 years. · Patented formulation, patent no.: ZL200410017941.2. Made in Singapore · Clinical trials published in the UK and US (Natural Product Reports 2004 and Life Sciences 2005). Also presented at the 4th International Conference on Natural Products 2006. · No known side effects. | |
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Scientific studies show that Kardigen has a host of cardioprotective benefits. As such, it is recommended for those with heart problems, especially post-myocardial infarction patients. Kardigen comes from purified Herba Leonuri extract (Chinese Motherwort), a herb that has been used for thousands of years. The patented extraction process isolates and concentrates five key active antioxidants, which help to improve microcirculation and eliminate blood stasis. It has no known side effects. KardiGen 3 AIMs: Pre & Post Myocardial Infarction Support Antioxidant Shield for the Heart § Round-the-Clock Shield with 5 Cardioprotective Antioxidants1: 1) Stachydrine (C7H13NO2) 2) Quercetin (C15H10O7) 3) Kaempferol (C15H10O6) 4) Leonurine (C14H21N3O5) and 5) Apigenin (C15H10O5), § Directly neutralizes harmful free radicals2,4: 1) Peroxynitrite (ONOO-), 2) Hypochlorous acid (HOCI), 3) Hydroxyl radical (OH-), 4) ABTS & 5) DPPH. § During myocardial infarction, KardiGen selectively preserves the activities of endogenous antioxidant enzymes 1) Superoxide Dismutase (SOD) and 2) Gluthione Peroxidase (GPx), and depresses the formation of malondialdehyde (MDA), to reduce infarct size in the acute phase of myocardial infarction1,3,4. § Inhibits Lipid Peroxidation more effectively than Vitamin E & C1. § Under AMI (Acute Myocardial Infarction) conditions, cardiomyocyte death could be due to both necrosis and apoptosis. KardiGen has been shown to attenuate AMI-induced apoptosis by down regulating the expression of pro-apoptotic genes P53, Fas and Bcl-xs4.
Survival Rate 24 hours after Acute Myocardial Infarction (AMI)
Ischemic Angiogenesis § Angiogenesis is stimulated only under ischemic conditions and not under normal conditions. This is useful post myocardial infarction, where new blood vessels grow in place of damaged ones3,4. § Improved angiogenesis is brought about by an increase in gene expression of vascular endothelial growth factor (VEGF) under hypoxic conditions3,4. § Studies show a 29% jump in new blood vessel density in the left ventricle after a 3-month treatment period3. Microcirculation § Promotes microcirculation and removes blood stasis1. § Increases diuresis to lower blood pressure1.
KardiGen is Suitable for: § Pre (high-risk group) & post myocardial infarction protection § Coronary heart disease § High blood pressure § High cholesterol § Ischemic stroke § Diabetes § Smokers § Health supplement References 1. Anti-oxidative stress effects of Herba leonuri on ischemic rat hearts. Sun J, Huang SH, Zhu YC, Whiteman M, Wang MJ, Tan BK, Zhu YZ. Faculty of Medicine, National University of Singapore and Fudan University Shanghai Medical College. Life Sci. 2005 May 13; 76(26):3043-56. 2. Antioxidants in Chinese herbal medicines: a biochemical perspective. Zhu YZ, Huang SH, Tan BK, Sun J, Whiteman M, Zhu YC. Faculty of Medicine, National University of Singapore. Nat Prod Rep. 2004 Aug; 21(4):478-89. 3. Therapeutic effects of Chinese herbal extracts after purification and standardization. Zhu YZ. National University of Singapore and Fudan University. 4th International Conference on Natural Products in Switzerland. 2006 May; PL11. 4. Protective effects of Herba Leonuri in Ischemic Models. National University of Singapore, Shanghai University of Traditional Chinese Medicine and Fudan University. Natural Products: Essential Resources for Human Survival. 2007. 347-364.
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